Other types of antidepressants, such as monoamine oxidase inhibitors (MAOIs), have also been known to cause serotonin syndrome when combined with certain substances of abuse like MDMA. While research has shown that SSRI antidepressants do not typically have severe drug reactions, there is concern that combining SSRIs with MDMA can lead to serotonin syndrome. This can cause even lower lows - a dangerous prospect for the clinically depressed. At this time, antidepressants are not as effective. MDMA initially floods the brain with serotonin, and then there’s a crash period when the brain produces very little serotonin. Serotonin Syndromeīecause MDMA can interfere with antidepressant efficacy, it has the risk of making depression even worse. This means that, ultimately, taking the two together decreases the efficacy of both. The truth is that antidepressants and MDMA both compete for access to the same neurons. There is a common misconception that taking MDMA with antidepressants helps to enhance their effects. Even so, this does not mean that taking them in combination is without repercussions. They are on antidepressants in their everyday life, and they don’t think about how MDMA will potentially react with these medications.Īccording to a publication from Columbia University, the research predominantly shows there are little to no dangerous drug reactions that occur from taking MDMA and antidepressants together. Other people just want to take MDMA recreationally. This kind of self-medication is dangerous. Many believe that ecstasy is an effective antidepressant, so they may attempt to use the drug to replace or enhance the effects of their antidepressants. MDMA and antidepressants are sometimes combined.
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